Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors.
نویسندگان
چکیده
Binding of Leu-enkephalin and [Rh(III)(η(5)-Cp*)(η(6)-Tyr(1))]Leu-enkephalin to the recently published crystal structures of the μ- and δ-opioid receptor is studied. Docking of free Leu-enkephalin reveals two preferred conformations, one of which suggests an alternative binding site for the tyrosine residue. Furthermore, the three-dimensional solution structure of [Rh(III)(η(5)-Cp*)(η(6)-Tyr(1))]Leu-enkephalin was solved by using 2D NMR spectroscopic techniques.
منابع مشابه
اپوئیدها(Opioids) و دستگاه گوارش
SUMMARY The term opioid was coined to refer in a generic sense to all drugs, natural and synthetic, with morphin - like actions. Three distinct families of peptides have been identified so far in gastrointestinal (GI) nervous system in mammalian. These peptides include : dynorphin, Met - enkephalin and leu - enkephalin . Results from studies about opioid which have been started 15 years ago ...
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عنوان ژورنال:
- Dalton transactions
دوره 42 27 شماره
صفحات -
تاریخ انتشار 2013